PHAR2102 Wk 11 Tutorial Renal IH 2024 PDF

PHAR2102: Cardiovascular and Renal Health Week 11 Tutorial 10: Renal etc Assoc Prof Ian Heslop [email protected]  Plan/aims for the tutorial Review/Revise key issues re: 1. General renal starting questio...

PHAR2102: Cardiovascular and Renal Health Week 11 Tutorial 10: Renal etc Assoc Prof Ian Heslop [email protected]  Plan/aims for the tutorial Review/Revise key issues re: 1. General renal starting questions 2. Dosage adjustment in renal impairment 3. Causes and management of ARF 4. Differences between ARF and CKD 5. Management of CKD 6. Renal replacement therapies N.B. Can’t cover all key points in a 2-hr tutorial – you need to also review lecture material etc  1. General Renal Starting Questions 1. What are the key functions of the kidneys? A. How do these systems work? B. How are the affected in ARF and CKD? 2. How is GFR regulated? 3. How do we estimate GFR?  1. General Starting Questions 1. What are the key functions of the kidneys? Kidney has following functions: Elimination of waste/surplus Regulation of fluid and electrolyte balance Endocrine homeostasis Balance of K+, Na+ and H2O Elimination of Phosphate, nitrogenous waste and uremic toxins Elimination/clearance of drugs and drug metabolite Erythropoiesis Acid-base balance Activation of vitamin D A. How do these systems work? – See lecture notes and later B. How are the affected in ARF and CKD? – See lecture notes and later 2. How is GFR regulated? – See lecture notes and later 3. How do we estimate GFR? – See lecture notes and later  2. Dosage adjustment in renal impairment A. How do we categorise renal impairment? (from a dosage adjustment perspective) B. How do we estimate renal function or calculate Creatinine Clearance? C. In what situations can calculations of CrCl be less reliable? D. When prescribing a medication in renal impairment, what do we need to consider? E. Case scenario 1 – Dose adjustments in renal impairment A. How do we categorise renal impairment? (from a dosage adjustment perspective) Drug dosing in renal failure Degree of renal impairment: Mild renal impairment 25-50 ml/min Moderate renal impairment 10-25 ml/min Severe renal impairment