Pentose Phosphate Pathway PDF
Document Details
Ma. Cristina F. T. Dimaculangan
Tags
Related
- Pentose Phosphate Pathway PDF
- Pentose Phosphate Pathway Biochemistry PDF
- Glucose Tests, Gluconeogenesis, Pentose Phosphate Pathway, & Other CHO Metabolism PDF
- Glucose Tests, Gluconeogenesis, & Pentose Phosphate Pathway PDF
- Harper's Biochemistry Chapter 20 - The Pentose Phosphate Pathway PDF
- Lecture 23: Pentose Phosphate Pathway (PDF)
Summary
These notes provide an overview of the Pentose Phosphate Pathway (PPP), including its function in biosynthesis and the synthesis of important molecules like ribose-5-phosphate, glyceraldehyde-3-phosphate, and fructose-6-phosphate. The document details the pathway's oxidative and non-oxidative phases and touches on its regulation. Useful for learning about metabolism and cell biology.
Full Transcript
11/12/2023 PPP Hexosemonophosphate shunt Phosphogluconate pathway Pentose Phosphate Pathway...
11/12/2023 PPP Hexosemonophosphate shunt Phosphogluconate pathway Pentose Phosphate Pathway Oxidative pathway Electron acceptor: NADP+ Ma. Cristina F. T. Dimaculangan Site: Cytosol 2 phases – Oxidative – Non-oxidative 1 2 Function of PPP NADPH Products are used for biosynthesis Products: – Reducing agent in the cell NADPH – For reductive biosynthesis Ribose – Reduces double bonds Interconverts sugars – Proton donor – Lipid synthesis/fatty acid synthesis 3 4 Ribose-5-Phosphate Interconverts sugars – ATP Triose – CoA tetrose – NAD Pentose – FAD Hexose – RNA – DNA Heptose Series of non-oxidative reactios 5 6 1 11/12/2023 https://med.libretexts.org/Bookshelves/Basic_Sci ence/Cell_Biology_Genetics_and_Biochemistry_f or_Pre- Clinical_Students/07%3A_Pentose_phosphate_p athway_(PPP)_purine_and_pyrimidine_metabolis m/7.01%3A_Pentose_phosphate_pathway#:~:tex t=The%20pentose%20phosphate%20pathway%2 0(PPP,to%20the%20production%20of%20NADP H. 7 8 Oxidative Phase oxidation hydrolysis Oxidative decarboxylation 9 10 Oxidative Phase Transketolase Reaction Produces NADPH – for reductive processes (lipid biosynthesis) – antioxidant mechanisms – For cells that produce large amounts of lipids (adipose tissue, adrenal cortex, mammary glands, and the liver) Requires TPP (thiamine pyrophosphate), – For RBCs coenzyme form of thiamine, Vit. B1) Transfers a ketose to an aldose 11 12 2 11/12/2023 Non-oxidative Phase Non-oxidative Phase 13 14 Products of Non-oxidative Pathway synthesis of – ribose- 5-phosphate – glyceraldehyde-3-phosphate – fructose-6-phosphate. 15 16 PPP Regulation 17 18 3
