OSPE Pathology Questions PDF

Questions on Case #1 2 1 What is the affected tissue? Artery. What is the diagnosis ? Fibrinoid necrosis in an a...

Questions on Case #1 2 1 What is the affected tissue? Artery. What is the diagnosis ? Fibrinoid necrosis in an artery. Identify the labelled structure: 1- Endothelial and inflammatory cells 2- Pink fibrinous material/ The wall of the artery shows a circumferential bright pink area of necrosis with inflammation. Mention two main causes that lead to this condition? 1-Autoimmune diseases 2- Malignant hypertension Mention two microscopic features: 1-Circumferential bright pink area of fibrinoid necrosis 2- marked/severe inflammation or vasculitis (neutrophils with dark nuclei)  Questions on Case #2 Identify the labelled structures: - Lymphocytes - Blood vessels - Normal cells (normal columnar epithelium) – Squamous Metaplasia Describe what is seen in picture? In the center, focus of squamous metaplasia of endocervix but at the both margin shows the normal columnar epithelium Is it Atypical or not? It’s Typical, just one type of cells replaced by another type (metaplasia not dysplasia) what is the diagnosis? The diagnosis is Typical squamous metaplasia of endocervix When it’s all dysplastic and the dysplasia is involved in the full thickness from basal layer to superficial, the name is : (the form where the biopsy shows atypical squamous cells throughout the entire thickness of the epithelium is called?) Squamous carcinoma in-situ and when invading the basal layer is called malignant tumor What is the cause of this condition? The columnar cells are replaced by squamous cells Mention the microscopical features seen in picture? - normal columnar epithelium at both margins - central focus of squamous metaplasia - lymphocytic infiltration  Questions on Case #3 A 28 year old woman came to the ER with sever pain in the upper right region of the abdomen. The doctor admitted her for immediate excision by surgery. What is the excised organ that shown in the gross picture? Gallbladder Write one gross feature Congestion, redness, thickness of the wall Give two histopathological features in the Histological picture infiltration of many neutrophils in the mucosa of the gallbladder, vascular congestion What is the diagnosis? Acute cholecystitis What is the probable etiology? Stone obstructed the neck Identify the structures pointed in figure 1 Red arrow: vascular congestion Blue arrow: neutrophils  Questions on Case #4 Histological picture Gross picture What is the type of the inflammation here? Chronic granulomatous inflammation Identify the cells in the histological picture epithelioid cells Langhans giant cell Describe what you see in the gross picture: Swelling and scarring. What is the diagnosis? Tuberculous lymphedenitis What is the type of necrosis if present? Caseous necrosis Is the disease caused by a microorganism? If yes What is the causative microorganism? Similar question: what is the etiology of the disease. Yes, Mycobactirium tuberculosis What is the stain used? And color (appearance) Name: Acid fast bacilli (AFB) stain or ziehl neelsen stain Color (appearance) : Red or pink color and rods shape  Questions on Case #5 figure 2 figure 1 Identify the labelled structures in figure 1 Melanocytes (nevus cell) Melanophages What is the diagnosis ? Intradermal Nevus (Benign) What is the malignant tumor? Melanoma What is the characteristic appearance (features) of the cells in figure 2? 1-The cells are small, round, or spindle-shaped, typically arranged in nests and clusters 2-symmetrical (Circumscribed) 3-has different colors (Pink – Tan – Brown etc) Give two histopathologic features: 1-Proliferating benign intradermal melanocytes 2-nevus cells containing melanin pigment.  OLOGY TEA TH M PA OSPE Pathology team Mohammed Fahad Alruwaily Alnoshan Battal Aljohani Ruba aldibas Abdulaziz Noor Mohammed Alshareef Jood Alqosi