Drugs for Atherosclerosis Prevention PDF

 for Atherosclerotis Prevention Drugs : drug class · mechanism of action Inhibit...

 for Atherosclerotis Prevention Drugs : drug class · mechanism of action Inhibit HMG-Co adverse effect myopathy /Improper first therapeutic effect/use line treatment function for lowering LDL ↳ rate limiting step musch statins in cholesterol synthesis· ↑ liver enzymes cholesterol levels Censures more is removed than produced · inhibits transporte · typically used w/ Stero Absorption in GI responsible statins Inhibitor for Cholestero absorption (ex Ezetimibe) ↳ levels plasma · reduces VLDL levels by : rashes treate hypertriglyceridemia · Fibric Acid O ↑ breakdown of · El upset 14 triglycerides3 VLDL) Derivatives pancreatitis triglycerides in myopathy · · /ex , gemEbrozil) &I VLDL secretion · hyperkalemia genfibrozil used to by liver, freut ↑ cholesterol ③ I breakdown of fatty acids in adipose tissue > - bind bile acids · bloating ↓ LDL (20 1 ).. Bile Acid In Intestine , inhibiting Constipation · Binding their reabsorption , Resing their enhancing (ex Cholestyramine). excretion a ↳ cholesterol - > bile in liver , ↓ LDL-cholesterol 100 % 1) monoclonal mild hyperlipoproteinemia > - > - they are skin rxn antibodies targeted against upper resp ↳ ↓ LDL by 60 -70 % peSka the pasha protein tract infection when other drugs don't Inhibitors 4 > - the livers limitation = $$ work (last resort drug) , lex Alirocumab and. ability to remove difficulty wh ↳ if super high LDL Evolocumab) cholesterol from compliance (infection or issues I compliance blood 2-4 weeks) every ①Statins ↳ Inhibit (rate HMG-CoA step biosynthes limiting in cholestoral ② Stero absorption Inhibitors ↳ decrease absorption of cholesterd and bil in G ② Fibrie acid derivatives - a VLDL secretion a ↳ breakdown of triglyceride of fatty ↳ ↓ acids in adipose tissue ④ Bile acid binding resins ↳ bind I Synthesis of bil from bile reabsorption , inhibiting , cholestero in liver ⑤ pscha Inhibitor ↳ Inhibit PSCE9 ↑ livers to remove cholester from blood , ability