Pharmacology Quiz - Anticoagulant Drugs PDF

Pharmacology Quiz - Anticoagulant Drugs Part One: Simple MCQs 1. Which of the following is NOT a parenteral anticoagulant? ○ (a) Heparin ○ (b) Warfarin ○ (c) Bivalirudin ○ (d) Argatroban 2. Which anticoagulant drug acts by inhibiting vitamin K epoxide reductase? ○ (a) Heparin ○ (b) War...

Pharmacology Quiz - Anticoagulant Drugs Part One: Simple MCQs 1. Which of the following is NOT a parenteral anticoagulant? ○ (a) Heparin ○ (b) Warfarin ○ (c) Bivalirudin ○ (d) Argatroban 2. Which anticoagulant drug acts by inhibiting vitamin K epoxide reductase? ○ (a) Heparin ○ (b) Warfarin ○ (c) Dabigatran ○ (d) Bivalirudin 3. What is the primary mechanism of action of heparin? ○ (a) Direct inhibition of thrombin ○ (b) Inhibition of vitamin K epoxide reductase ○ (c) Activation of antithrombin III ○ (d) Inhibition of factor Xa 4. Which anticoagulant is monitored using the activated partial thromboplastin time (APTT)? ○ (a) Warfarin ○ (b) Heparin ○ (c) Dabigatran ○ (d) Rivaroxaban 5. Which of the following is a potential adverse effect of both heparin and warfarin? ○ (a) Thrombocytopenia ○ (b) Bleeding ○ (c) Osteoporosis ○ (d) Hemorrhagic skin necrosis 6. Which drug is used to reverse the anticoagulant effects of heparin? ○ (a) Vitamin K ○ (b) Protamine sulfate ○ (c) Fresh frozen plasma ○ (d) None of the above 7. Which of the following is an oral direct thrombin inhibitor? ○ (a) Bivalirudin ○ (b) Argatroban ○ (c) Dabigatran ○ (d) Rivaroxaban 8. Which anticoagulant is known to have a delayed onset of action? ○ (a) Heparin ○ (b) Warfarin ○ (c) Dabigatran ○ (d) Bivalirudin 9. Which of the following drugs can potentiate the anticoagulant effect of warfarin? ○ (a) Phenobarbital  ○ (b) Rifampin ○ (c) Cimetidine ○ (d) Oral contraceptives 10. Which of the following is NOT an indication for anticoagulant therapy? ○ (a) Prevention of venous thrombosis ○ (b) Treatment of deep vein thrombosis ○ (c) Atrial fibrillation ○ (d) Hemophilia Part Two: Complex MCQs 11. A patient on warfarin therapy develops a major bleeding episode. Which of the following interventions would be most appropriate to manage this situation? ○ (a) Administer protamine sulfate ○ (b) Discontinue warfarin and administer vitamin K ○ (c) Increase the dose of warfarin ○ (d) Switch to heparin therapy 12. A patient with a history of heparin-induced thrombocytopenia requires anticoagulation for a surgical procedure. Which of the following drugs would be the most suitable alternative? ○ (a) Warfarin ○ (b) Low-molecular-weight heparin ○ (c) Bivalirudin ○ (d) Unfractionated heparin 13. A patient is prescribed warfarin for the prevention of stroke in atrial fibrillation. Which of the following laboratory tests would be used to monitor the therapeutic effect of warfarin? ○ (a) Activated partial thromboplastin time (APTT) ○ (b) Prothrombin time (PT) and International Normalized Ratio (INR) ○ (c) Platelet count ○ (d) Bleeding time 14. Which of the following statements best describes the advantages of newer oral anticoagulants (e.g., dabigatran, rivaroxaban) over warfarin? ○ (a) They require frequent laboratory monitoring ○ (b) They have a higher risk of bleeding ○ (c) They have a rapid onset of action and fewer drug interactions ○ (d) They are less effective in preventing thromboembolic events 15. A pregnant woman with a mechanical heart valve requires anticoagulation throughout her pregnancy. Which of the following regimens is the most appropriate? ○ (a) Warfarin throughout pregnancy ○ (b) Low-molecular-weight heparin throughout pregnancy ○ (c) Low-molecular-weight heparin until 13 weeks' gestation, then warfarin until 34 weeks, then switch back to low-molecular-weight heparin ○ (d) No anticoagulation during pregnancy 16. Which of the following is a potential consequence of abruptly discontinuing warfarin therapy? ○ (a) Increased risk of bleeding ○ (b) Thrombotic complications ○ (c) Heparin-induced thrombocytopenia ○ (d) Osteoporosis 17. A patient on warfarin therapy is started on a course of antibiotics for a bacterial infection. What effect might this have on the patient's INR? ○ (a) The INR would likely decrease ○ (b) The INR would likely increase ○ (c) The INR would likely remain unchanged ○ (d) Antibiotics have no effect on INR 18. Which of the following statements about low-molecular-weight heparin (LMWH) is FALSE? ○ (a) It has a longer half-life than unfractionated heparin ○ (b) It has a lower risk of thrombocytopenia than unfractionated heparin ○ (c) It requires frequent laboratory monitoring ○ (d) It is more specific for factor Xa than unfractionated heparin 19. A patient with a history of peptic ulcer disease requires anticoagulation. Which of the following drugs would be the least suitable choice? ○ (a) Heparin ○ (b) Warfarin ○ (c) Dabigatran ○ (d) Rivaroxaban 20. Which of the following is NOT a contraindication to anticoagulant therapy? ○ (a) Hemophilia ○ (b) Recent hemorrhagic stroke ○ (c) Atrial fibrillation ○ (d) Active peptic ulcer 21. Which of the following statements about the coagulation system is TRUE? ○ (a) It consists of a series of plasma proteins that activate each other to form a clot ○ (b) The intrinsic and extrinsic pathways converge on the common pathway ○ (c) Fibrinogen is converted to fibrin, which forms the meshwork of a clot ○ (d) All of the above 22. A patient is started on heparin therapy and develops thrombocytopenia. What is the most likely cause of this adverse effect? ○ (a) Vitamin K deficiency ○ (b) Immune-mediated reaction ○ (c) Drug interaction with warfarin ○ (d) Overdose of heparin 23. Which of the following is a characteristic of bivalirudin? ○ (a) It is a synthetic coumarin compound ○ (b) It is administered orally ○ (c) It is a reversible direct thrombin inhibitor ○ (d) It has a long duration of action 24. A patient with a prosthetic heart valve is planning a pregnancy. Which of the following statements regarding anticoagulation during pregnancy is most accurate? ○ (a) Warfarin is safe to use throughout pregnancy ○ (b) Anticoagulation is not necessary during pregnancy ○ (c) Low-molecular-weight heparin is the preferred anticoagulant throughout pregnancy ○ (d) Anticoagulation management should be individualized and may involve switching between LMWH and warfarin during different trimesters 25. Which of the following drugs can decrease the anticoagulant effect of warfarin by inducing its metabolism? ○ (a) Cimetidine  ○ (b) Chloramphenicol ○ (c) Rifampin ○ (d) Oral antibiotics Answer Guide Part One 1. b 2. b 3. c 4. b 5. b 6. b 7. c 8. b 9. c 10. d Part Two 11. b 12. c 13. b 14. c 15. c 16. b 17. b 18. c 19. b 20. c 21. d 22. b 23. c 24. d 25. c Done