IBS/IBD Medication Questions PDF

1. What is the mechanism of action of sulfasalazine? a) Inhibits dihydrofolate reductase b) Reduces inflammation by releasing 5-aminosalicylic acid (5-ASA) in the gut c) Blocks TNF-alpha receptors d) Suppresses purine synthesis Answer: b) Reduces inflammation by releasing 5-aminosalicylic acid (5-AS...

1. What is the mechanism of action of sulfasalazine? a) Inhibits dihydrofolate reductase b) Reduces inflammation by releasing 5-aminosalicylic acid (5-ASA) in the gut c) Blocks TNF-alpha receptors d) Suppresses purine synthesis Answer: b) Reduces inflammation by releasing 5-aminosalicylic acid (5-ASA) in the gut 2. Which adverse effect is commonly associated with sulfasalazine? a) Nephrotoxicity b) Photosensitivity c) Pulmonary fibrosis d) QT prolongation Answer: b) Photosensitivity 3. What is the primary indication for budesonide in IBD? a) Severe ulcerative colitis b) Mild to moderate Crohn’s disease c) Refractory Crohn’s disease d) Maintenance of remission in ulcerative colitis Answer: b) Mild to moderate Crohn’s disease 4. Which black-box warning is associated with azathioprine? a) Risk of tendon rupture b) Increased risk of malignancy c) Severe QT prolongation d) Hepatotoxicity Answer: b) Increased risk of malignancy 5. What monitoring is required for azathioprine use? a) Blood glucose levels b) Liver function tests and CBC c) Renal function and potassium d) Calcium and phosphorus levels Answer: b) Liver function tests and CBC 6. Which enzyme deficiency increases the risk of toxicity from azathioprine? a) Dihydrofolate reductase b) TPMT (thiopurine methyltransferase) c) Cytochrome P450 3A4 d) Adenosine deaminase Answer: b) TPMT (thiopurine methyltransferase) 7. What is the mechanism of action of mercaptopurine? a) Inhibits dihydrofolate reductase b) Inhibits purine synthesis c) Blocks TNF-alpha receptors d) Prevents immune cell migration Answer: b) Inhibits purine synthesis 8. Which side effect is most commonly associated with cyclosporine? a) Gingival hyperplasia b) Photosensitivity c) Hepatotoxicity d) Pancreatitis Answer: a) Gingival hyperplasia 9. Which condition is infliximab primarily used to treat? a) Mild Crohn’s disease b) Moderate to severe ulcerative colitis c) Constipation-predominant IBS d) Functional dyspepsia Answer: b) Moderate to severe ulcerative colitis 10. What is the mechanism of action of infliximab? a) Suppresses immune cell migration b) Blocks TNF-alpha to reduce inflammation c) Inhibits purine synthesis d) Prevents B-cell activation Answer: b) Blocks TNF-alpha to reduce inflammation 11. What is a black-box warning for infliximab? a) Pulmonary fibrosis b) Risk of serious infections and malignancy c) Renal toxicity d) QT prolongation Answer: b) Risk of serious infections and malignancy 12. Which adverse effect is most commonly associated with methotrexate? a) Nephrotoxicity b) Pulmonary fibrosis c) QT prolongation d) Gingival hyperplasia Answer: b) Pulmonary fibrosis 13. What is the mechanism of action of methotrexate? a) Inhibits dihydrofolate reductase, suppressing DNA synthesis b) Inhibits purine synthesis c) Blocks TNF-alpha receptors d) Prevents immune cell migration Answer: a) Inhibits dihydrofolate reductase, suppressing DNA synthesis 14. Which medication is most effective for maintenance of remission in ulcerative colitis? a) Budesonide b) Mesalamine c) Azathioprine d) Infliximab Answer: b) Mesalamine 15. Which IBD medication is associated with nephrotoxicity and requires renal monitoring? a) Methotrexate b) Cyclosporine c) Infliximab d) Mercaptopurine Answer: b) Cyclosporine 16. What is the main role of budesonide in IBD treatment? a) Long-term maintenance therapy b) Short-term induction of remission c) Management of refractory fistulas d) Prevention of colorectal cancer Answer: b) Short-term induction of remission