Dopamine PDF

GENERIC NAME dopamine TRADE, BRAND, OR PROPRIETARY NAME Intropin® CLASSES Sympathomimetic Vasopressor STANDARD SUPPLY Premix bag for infusion MECHANISMS OF ACTION Increases the heart rate Increases the force of myocardial contractility Increases the blood pressure Increases preload INDICATIONS Cardi...

GENERIC NAME dopamine TRADE, BRAND, OR PROPRIETARY NAME Intropin® CLASSES Sympathomimetic Vasopressor STANDARD SUPPLY Premix bag for infusion MECHANISMS OF ACTION Increases the heart rate Increases the force of myocardial contractility Increases the blood pressure Increases preload INDICATIONS Cardiogenic shock Hemodynamically significant bradycardia Hemodynamically significant hypotension CONTRAINDICATION Hemodynamically significant hypovolemic shock ADVERSE REACTIONS/SIDE EFFECTS Extravasation may cause tissue necrosis Increased myocardial oxygen demand Tachycardia Hypertension Dysrhythmias Dyspnea Tremors Palpitations Headache Nausea Vomiting ROUTE OF ADMINISTRATION Infusion DOPAMINE 1 ONSET OF ACTION 1 to 4 minutes THERAPEUTIC DOSAGE RANGE & RESPONSES 2.0 to 5.0 mcg/kg/minute: o Negligible beta-adrenergic response 5.0 to 10 mcg/kg/minute: o Beta-adrenergic responses  Positive chronotropic effects  Positive inotropic effects 10 to 20 mcg/kg/minute: o Alpha-adrenergic responses  Vasoconstriction  Increased blood pressure  Increased preload > 20 mcg/kg/minute: o May increase the heart rate and myocardial oxygen demand to undesirable limits ADULT DOSAGES Infusion: 2.0 to 20 mcg/kg/minute (reference the Dopamine Dosage Table) PEDIATRIC DOSAGES Infusion: 2.0 to 20 mcg/kg/minute SPECIAL CONSIDERATIONS The peak effect of the drug is 5 to 10 minutes The duration of the drug is variable An infusion pump should be used to administer the drug when possible DOPAMINE 2