CHEM283: Lecture 1 - Fall 2024 (PDF)

CHEM283: Lecture 1 Human Cell (Model) Welcome! Dr. Yasir Raouf Department of Chemistry United Arab...

CHEM283: Lecture 1 Human Cell (Model) Welcome! Dr. Yasir Raouf Department of Chemistry United Arab Emirates University Fall 2024 Matter And Biochemistry for Non-Majors 1 Measurement CHEM283: Lecture 1 Instructor: Dr. Yasir Raouf Education: Ph.D., University of Toronto, Canada B.Sc. (Hons.), University of Toronto, Canada Research: Medicinal chemistry (Oncology), Biochemistry, Organic synthesis Computer-aided drug design (CADD), Cancer epigenetics, Drug discovery Contact Information: [email protected] Office Location: C6 2043 Office Hours: Monday and Wednesday (3:00 PM – 4:00 PM) Matter And Biochemistry for Non-Majors 2 Measurement CHEM283: Lecture 1 Course Overview (15 weeks): 1. Introduction, Cell Morphology, Acids/Bases, and Buffers 2. Protein Structure and Function 3. Enzymes 4. Carbohydrate Chemistry 5. Carbohydrate Metabolism + Soft skills! 6. Aerobic Respiration 7. Lipids and Fatty Acids 8. Fatty Acid Metabolism 9. Molecular Genetics Matter And Biochemistry for Non-Majors 3 Measurement CHEM283: Lecture 1 Course Assessment: Matter And Biochemistry for Non-Majors 4 Measurement CHEM283: Lecture 1 Course Textbook: General, Organic, and Biochemistry, 8th or 11th edition, Authors: K.J. Denniston, J.J. Topping and R.L. Caret, Published by: Mc Graw Hill Any Questions? Matter And Biochemistry for Non-Majors 5 Measurement CHEM283: Lecture 1 Class Attendance Matter And Biochemistry for Non-Majors 6 Measurement CHEM283: Lecture 1 Lesson Plan: 1. An Overview of Biochemistry: History & Milestones 2. Chapter 8: Introduction Central Dogma of Life Functional Groups & Biological Macromolecules “Biochemistry is a practical, experimental Applications & Significance science, with applications in every part of our life, we just have to know where to look” Important 3. Summary & Conclusion Matter And Biochemistry for Non-Majors 7 Measurement CHEM283: Lecture 1 Preface A Brief Overview of Biochemistry History & Milestones Matter And Biochemistry for Non-Majors 8 Measurement  CHEM283: Lecture 1 Hooke (1665) Lavoisier (1775) Miescher (1869) Buchner (1900) Krebs (1937) Microscope Photosynthesis (CO2, H2O) Nucleus (Animal cell) Enzymes Citric Acid Cycle Levine, Avery, Chargaff (1930-1945) Franklin, Watson, Crick (1953) Genetic Material is within DNA Structure of DNA (Double Helix) Nobel Prize in Chemistry Twice! ? Sanger (1958) Doudna, Charpentier (2020) Who’s Next? Discovery of first protein - Insulin Genome Editing (CRISPR-Cas9) Matter And Biochemistry for Non-Majors 9 Measurement  CHEM283: Lecture 1 Chapter 8 Macromolecules, Cells, Acids, Bases & Buffers Matter And Biochemistry for Non-Majors 10 Measurement CHEM283: Lecture 1 In the simplest way, Biochemistry involves the use of Chemistry to study Biological processes at the molecular, and cellular levels… Biochemistry = Chemistry of Life! This involves: Chemistry, physics, immunology, pharmacology, etc. Matter And Biochemistry for Non-Majors 11 Measurement CHEM283: Lecture 1 The Central Dogma of Biology: From Genetic Code to Structure/Function Describes the flow of genetic information from DNA to RNA to Proteins DNA: Replication DNA to RNA: Transcription RNA to Protein: Translation (Protein synthesis) Important Concept Matter And Biochemistry for Non-Majors 12 Measurement CHEM283: Lecture 1 The Central Dogma of Biology: From Genetic Code to Structure/Function Describes the flow of genetic information from DNA to RNA to Proteins DNA: Replication DNA to RNA: Transcription RNA to Protein: Translation (Protein synthesis) Important Concept Matter And Biochemistry for Non-Majors 13 Measurement CHEM283: Lecture 1 The Central Dogma of Biology: From Genetic Code to Structure/Function Any Questions? Matter And Biochemistry for Non-Majors 14 Measurement  CHEM283: Lecture 1 The Elements of Life… Element Plants Animals C 12% 19% H 10% 10% N 1% 4% O 77% 63% P