photo.jpg

## Trail of the elucidation of DNA molecular structure * Rosalind Franklin, Gosling and Maurice Wilkins (Kings College London) * Helical DNA structure, sugar and phosphate background outside, while nucleotides are tucked inside * James Watson and Francis Crick (Cambridge University) * Tripl...

## Trail of the elucidation of DNA molecular structure * Rosalind Franklin, Gosling and Maurice Wilkins (Kings College London) * Helical DNA structure, sugar and phosphate background outside, while nucleotides are tucked inside * James Watson and Francis Crick (Cambridge University) * Triple helix, phosphate in the center * Linus Pauling (Caltech) * Triple helix ### Other researchers consulted by Watson and Crick * John Griffith - Nucleotides are flat, stack up on top of another, possibility of A=T, C=G pairing. Crick saw the importance of specific pairing in replication process * Erwin Chargaff - purine-pyrimidine ratio is 1:1 (Chargaff's rule) * Jerry Donohue - H in the bases can change its position. This could be responsible for H bonding ### Publications of Watson and Crick * **Molecular Structure of Nucleic Acid.** *April 1953 Nature.* 1716 737-738. * **Genetic Implications of the Structure of Deoxyribonucleic Acid.** *May 1953 Nature.* 171: 964-967 ### Nobel Prize winner in 1962 for DNA configuration received by James Watson, Francis Crick and Maurice Wilkins. Rosalind was not included for she died in 1958.