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- **Somatostatin (peptide)** - Found in gastric/duodenal mucosa and pancreas - Release: stimulated by acid, inhibited by ACh - Inhibits release of all gut hormones - Directly inhibits parietal cell acid secretion - Mediates acid induced inhibition of gastrin release - **Histamine...

- **Somatostatin (peptide)** - Found in gastric/duodenal mucosa and pancreas - Release: stimulated by acid, inhibited by ACh - Inhibits release of all gut hormones - Directly inhibits parietal cell acid secretion - Mediates acid induced inhibition of gastrin release - **Histamine** - Gastrin and Ach cause release from cells in stomach - Stimulates acid secretion - Histamine H2 receptor blockers →↓ Acid secretion - Cimetidine (Tagamet), Ranitidine (Zantac)

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somatostatin histamine gastrointestinal hormones

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