Which modification leads to the inactivation of NFκB?
Understand the Problem
The question is asking for the specific modification that results in the inactivation of NFκB, which involves understanding the roles of different biochemical modifications and interactions within the NFκB signaling pathway.
Answer
Dephosphorylation of IκBα leads to NFκB inactivation.
Dephosphorylation of IκBα leads to the inactivation of NFκB.
Answer for screen readers
Dephosphorylation of IκBα leads to the inactivation of NFκB.
More Information
The dephosphorylation of IκBα prevents its degradation, allowing it to bind to NFκB and sequester it in the cytoplasm, thereby preventing the activation of NFκB target genes.
Tips
Confusing phosphorylation with dephosphorylation can lead to incorrect conclusions about NFκB activation or inactivation.
Sources
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