Which cyclin is primarily involved in the G1 to S phase transition?
Understand the Problem
The question is asking about the specific cyclin that plays a key role in the transition from the G1 phase to the S phase in the cell cycle. This involves knowledge of cell biology and the regulation of the cell cycle by different cyclins and CDKs.
Answer
D-type cyclins
The final answer is D-type cyclins.
Answer for screen readers
The final answer is D-type cyclins.
More Information
D-type cyclins activate CDK4 and CDK6, leading to phosphorylation of the retinoblastoma tumor-suppressor protein, which is crucial for the G1 to S phase transition.
Tips
A common mistake is confusing the role of other cyclins such as cyclin E, which is also involved in the G1/S transition but acts later.
Sources
- Cell cycle control - sciencedirect.com
- Control of cell cycle transcription during G1 and S phases - pmc.ncbi.nlm.nih.gov
- G1/S Transition - an overview - sciencedirect.com
AI-generated content may contain errors. Please verify critical information
