The phosphoinositide cascade is characterized by the activation of phospholipase C that initiates a sequence of events including all of the following except: a. conversion of PIP2... The phosphoinositide cascade is characterized by the activation of phospholipase C that initiates a sequence of events including all of the following except: a. conversion of PIP2 to PIP3. b, increase in cytosolic Ca2+ concentration. c. release of DAG from PIP2. d. activation of protein kinase C. e. phosphorylation of target proteins on serine/threonine residues.
Understand the Problem
The question pertains to the phosphoinositide cascade, a signaling pathway activated by phospholipase C. It asks to identify which of the listed events is NOT a characteristic step in this cascade. Options include conversions and releases of various molecules, as well as activation and phosphorylation events.
Answer
A. conversion of PIP2 to PIP3.
The phosphoinositide cascade, when activated by phospholipase C, does not include the conversion of PIP2 to PIP3. Therefore, the answer is A.
Answer for screen readers
The phosphoinositide cascade, when activated by phospholipase C, does not include the conversion of PIP2 to PIP3. Therefore, the answer is A.
More Information
Phospholipase C (PLC) activation leads to the hydrolysis of PIP2 into DAG and IP3. IP3 then causes an increase in cytosolic Ca2+ leading to the activation of protein kinase C and subsequent phosphorylation of target proteins.
Tips
It's easy to confuse the order of events in signaling cascades. Careful review of the specific steps can help to avoid this.
Sources
- Solved Activation of phospholipase C initiates a sequence of - Chegg - chegg.com
- Phospholipase C Gamma1 - an overview | ScienceDirect Topics - sciencedirect.com
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