Create a schematic diagram showing the effects of insulin resistance leading to diabetes mellitus.

Understand the Problem

The question is asking to create a schematic diagram that illustrates the relationship between insulin resistance and the development of diabetes mellitus. This involves understanding the mechanisms of insulin resistance and its impact on glucose metabolism, which leads to diabetes.

Answer

Insulin resistance impairs glucose uptake, raising blood glucose, which eventually leads to β cell dysfunction and type 2 diabetes.

A schematic diagram illustrating the effects of insulin resistance leading to diabetes mellitus would show insulin resistance reducing glucose uptake by the liver, adipose, and skeletal muscle, leading to increased blood glucose levels. Over time, β cell dysfunction occurs, resulting in impaired insulin secretion and eventually type 2 diabetes.

Answer for screen readers

A schematic diagram illustrating the effects of insulin resistance leading to diabetes mellitus would show insulin resistance reducing glucose uptake by the liver, adipose, and skeletal muscle, leading to increased blood glucose levels. Over time, β cell dysfunction occurs, resulting in impaired insulin secretion and eventually type 2 diabetes.

More Information

Insulin resistance typically affects liver, adipose tissue, and skeletal muscle. Primary manifestations include elevated blood glucose levels due to reduced insulin efficiency, compensatory hyperinsulinemia, and eventually, pancreatic β-cell dysfunction leading to type 2 diabetes.

Tips

A common mistake is misunderstanding how insulin resistance can lead directly to both hyperglycemia and eventual pancreatic exhaustion, ultimately causing type 2 diabetes.

Sources

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