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Questions and Answers

What is the primary purpose of the protective liner in PowderJect?

  • To be removed before application and enable drug release (correct)
  • To enable drug release
  • To enhance the solubility of essential oils
  • To protect the skin during application

What type of polymers are typically used in a hydrophilic matrix?

  • PEG, PVP, and silicon rubbers (correct)
  • Lipophilic polymers
  • Hydrophobic polymers
  • Lipophobic polymers

What is the mechanism of transport controlled release in PowderJect?

  • Osmotic pressure
  • Erosion of a polymer matrix
  • Firing fine, solid particles through the stratum corneum (correct)
  • Diffusion through a membrane

What is the property of the matrix that affects the release of therapeutic proteins?

<p>Physicochemical properties (B)</p>
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What is the purpose of the adhesive layer in a transdermal patch?

<p>To adhere the patch to the skin (B)</p>
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What is the role of sonophoresis in transdermal delivery?

<p>To create a vibration that enhances permeation (A)</p>
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What is the mechanism of Macroflux technology?

<p>Vibration created by sound waves (A)</p>
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What is the primary component of a lipophilic matrix?

<p>Lipophilic polymers (B)</p>
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What is the purpose of the gel layer in a transdermal patch?

<p>To control the release of therapeutic proteins (A)</p>
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What is the role of the adhesive layer in a drug-dispersing layer?

<p>To adhere the drug-dispersing layer to the skin (C)</p>
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What is the primary function of the control membrane in the Transdermal Therapeutic System?

<p>To control the rate of drug release (B)</p>
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What type of properties are crucial for the polymer matrix in the Transdermal Therapeutic System?

<p>Hydrophilic and lipophilic (A)</p>
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What is the primary role of the adhesive foam pad in the Transdermal Therapeutic System?

<p>To hold the system in place on the skin (D)</p>
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What is the purpose of the occlusive baseplate in the Transdermal Therapeutic System?

<p>To prevent moisture loss from the skin (D)</p>
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What is the function of the protective peel strip in the Transdermal Therapeutic System?

<p>To protect the adhesive layer during storage (B)</p>
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What is the primary mechanism of drug release in the Transdermal Therapeutic System?

<p>Transport-controlled release (C)</p>
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What is the significance of the flexible polyurethane layer in the Transdermal Therapeutic System?

<p>It allows for flexibility and conformability to the skin (C)</p>
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What is the primary purpose of the microscopic drug reservoirs in the Transdermal Therapeutic System?

<p>To store the drug for prolonged delivery (A)</p>
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What is an essential characteristic of a medically acceptable skin adhesive?

<p>Non-irritating/unacceptable dermal reaction (C)</p>
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What is an important parameter to evaluate in a transdermal delivery system?

<p>In vitro drug release study (C)</p>
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What is a critical aspect of packaging in a transdermal delivery system?

<p>Easily removable release liner (D)</p>
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What is a physicochemical property that can affect the performance of a transdermal delivery system?

<p>API-excipient compatibility (A)</p>
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What is a key aspect of a transdermal delivery system's adhesive properties?

<p>Adequate skin adhesion (B)</p>
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What is a critical parameter to evaluate in a transdermal delivery system's stability test?

<p>Drug content (A)</p>
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What is a key aspect of transport controlled release in a transdermal delivery system?

<p>Consistent pharmacokinetic and pharmacodynamic properties (D)</p>
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What is a critical parameter to evaluate in a transdermal delivery system's in vitro drug release study?

<p>Release of the drug (A)</p>
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Study Notes

Adhesive Layers

  • Adhesive layer is used in drug-dispersing layers
  • Adhesive layer is usually hydrophilic or lipophilic in nature
  • Examples of lipophilic polymer matrix include gelatin, synthetic PEG, PVP, and silicon rubbers

Drug Matrix

  • Drug matrix is a type of dispersed homogeneous system
  • Drug matrix is usually hydrophilic and lipophilic polymer matrix
  • Therapeutic proteins can be used in drug matrix

Jet Injectors

  • Jet injectors use high pressure helium gas to fire fine solid particles through the stratum corneum
  • PowderJect is a type of jet injector that uses a protective liner which is removed before application
  • The protective liner enables drug release

Microdialysis

  • Microdialysis is a method of evaluating the properties of a drug delivery system
  • Evaluation parameters for microdialysis include percentage of moisture absorption, percentage of moisture loss, thickness of film, weight variation, drug content, and in vitro and in vivo drug release studies

Transdermal Therapeutic System

  • The Transderm-Nitro is a type of transdermal therapeutic system
  • The system consists of a control membrane, adhesive layer, and protective peel strip
  • The adhesive layer is used to ensure adequate skin adhesion
  • The system is used to release vaccines and other therapeutic agents through the skin

Sonophoresis

  • Sonophoresis is a method of enhancing transdermal drug delivery
  • Sonophoresis uses sound waves to create vibration, which increases the permeability of the skin
  • Sonophoresis is used to deliver vaccines and other therapeutic agents through the skin

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