Mendelian Inheritance: Autosomal and X-Linked

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Questions and Answers

In autosomal dominant inheritance, the trait appears in every ______ without skipping generations.

generation

In autosomal dominant inheritance, affected offspring will have at least one affected ______, except for new mutants.

parent

For autosomal recessive inheritance, all offspring of two ______ parents are affected.

affected

In autosomal recessive inheritance, ______ plus homozygous normal individuals equals 1/2 carriers among their offspring.

<p>carriers</p>
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For a cross between Aa x Aa in autosomal recessive inheritance, the segregation frequency is ______.

<p>1/4</p>
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In autosomal recessive inheritance, affected animals plus unrelated normal mating produce ______ offspring.

<p>normal</p>
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In autosomal recessive inheritance, the genetic relationship between two individuals is greater if they are a carrier of the same ______.

<p>mutant</p>
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In X-linked dominant inheritance, affected males plus normal females will result in affected ______.

<p>daughter</p>
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In X-linked dominant inheritance, the disorder is more common in affected ______ plus normal males, with 1/2 sons and 1/2 daughters affected.

<p>females</p>
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In X-linked dominant inheritance, if the occurrence of the trait is rare, the incidence in females is ______ that in males.

<p>twice</p>
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In X-linked dominant inheritance, affected offspring stem from at least one affected ______.

<p>parent</p>
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In X-linked recessive inheritance, all offspring of two affected ______ are affected.

<p>parents</p>
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In X-linked recessive inheritance, the probability of the disorder is lower in ______ than in males.

<p>females</p>
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In X-linked recessive inheritance, the disorder in females approximates the ______ of the incidence in males.

<p>square</p>
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According to Mendelian inheritance patterns, autosomal ______ traits appear in every generation without skipping.

<p>dominant</p>
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In autosomal ______ inheritance, the trait can skip generations, appearing only when two carrier parents pass on the affected allele.

<p>recessive</p>
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In X-linked ______ inheritance, a single affected X chromosome in males is sufficient to express the trait fully.

<p>recessive</p>
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Normal offspring from an affected parent plus normal equals normal under autosomal ______ inheritance.

<p>dominant</p>
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When analyzing X-linked ______ inheritance, consider that the incidence in females approximates the square of the incidence in males due to the chromosomal differences.

<p>recessive</p>
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The genetic relationship among individuals has a greater effect in autosomal ______ traits where consanguinity increases the chance of inheriting the same mutant allele.

<p>recessive</p>
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Flashcards

Autosomal Dominant

A type of inheritance where the trait appears in every generation without skipping.

Autosomal Dominant Offspring

In autosomal dominant inheritance, normal offspring from affected parent + normal equals normal.

Autosomal Recessive

A type of inheritance that may skip generations.

Aa x Aa segregation frequency

A cross between Aa x Aa gives a segregation frequency of 1/4.

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X-Linked Dominant inheritance

Affected males + normal females = affected daughter

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X-linked Recessive disorder

The disorder in females is approximately the square of the incidence in males.

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Study Notes

  • Mendelian types of inheritance dictate how traits are passed down through generations

Autosomal Dominant

  • This type of inheritance passes through generation without skipping anyone
  • Affected offspring have at least one affected parent, save for new mutations.
  • Normal offspring from an affected parent plus normal parent results in a normal offspring
  • Both males and females can be affected

Autosomal Recessive

  • This type of inheritance may skip generations
  • All offspring of two affected parents are affected
  • Males and females can be affected
  • Carriers plus homozygous normal parents, have a 1/2 chance of producing carrier offspring
  • The segregation frequency of the offspring of Aa x Aa parents is 1/4
  • Affected animals and unrelated normal animals result in phenotypically normal offspring
  • The greater the genetic relationship between two individuals, the likely the common ancestor carries the same mutant gene

X-Linked Dominant

  • Affected males plus normal females result in affected daughters
  • The disorder is common: affected females plus normal males results in, 1/2 of the sons, and 1/2 of the daughters being affected
  • If rare, the incidence in females is twice that in males
  • Affected offspring have at least one affected parent

X-Linked Recessive

  • May skip generations
  • All offspring of two affected parents are affected
  • Less females than males are affected
  • The incidence of the disorder in females is approximately the square of the incidence in males

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