Podcast
Questions and Answers
Which statement accurately distinguishes between aldoses and ketoses?
Which statement accurately distinguishes between aldoses and ketoses?
- Aldoses are composed of more than 20 sugar units, whereas ketoses are composed of only one or two sugar units.
- Aldoses contain a ketone functional group at the end of the carbon chain, whereas ketoses contain an aldehyde functional group in the middle.
- Aldoses are produced from carbon dioxide and water through hydrolysis, while ketoses are produced through dehydration.
- Aldoses contain an aldehyde functional group at the end of the carbon chain, whereas ketoses contain a ketone functional group in the middle. (correct)
What is the significance of a chiral center in the context of carbohydrates?
What is the significance of a chiral center in the context of carbohydrates?
- It is the center where energy is stored within the carbohydrate molecule.
- It determines whether a carbohydrate is a monosaccharide or a polysaccharide.
- It allows carbohydrates to be covalently linked with proteins.
- It is the carbon atom around which there are four different functional groups, enabling stereoisomerism. (correct)
How are glycoproteins and proteoglycans formed?
How are glycoproteins and proteoglycans formed?
- Through the combination of multiple monosaccharide units.
- Through the process of photosynthesis.
- By creating mirror images of carbohydrate molecules.
- By covalently linking carbohydrates with proteins. (correct)
If a molecule has the same molecular formula but a different spatial arrangement of atoms, it is called a what?
If a molecule has the same molecular formula but a different spatial arrangement of atoms, it is called a what?
Which of the following is an example of a polysaccharide, based on the information provided?
Which of the following is an example of a polysaccharide, based on the information provided?
Optical isomerism is a form of stereoisomerism. What is the relationship between molecules exhibiting optical isomerism?
Optical isomerism is a form of stereoisomerism. What is the relationship between molecules exhibiting optical isomerism?
Which of the following is not a primary function of carbohydrates in biological systems?
Which of the following is not a primary function of carbohydrates in biological systems?
What distinguishes a disaccharide from a polysaccharide?
What distinguishes a disaccharide from a polysaccharide?
Based on the information, what is produced during photosynthesis?
Based on the information, what is produced during photosynthesis?
Which of the following correctly lists the molecules from smallest to largest, based on their number of sugar units?
Which of the following correctly lists the molecules from smallest to largest, based on their number of sugar units?
Considering the structure of carbohydrates with multiple chiral centers, which carbon atom is used to determine if the molecule is a D or L stereoisomer?
Considering the structure of carbohydrates with multiple chiral centers, which carbon atom is used to determine if the molecule is a D or L stereoisomer?
What distinguishes alpha-D-glucose from beta-D-glucose?
What distinguishes alpha-D-glucose from beta-D-glucose?
Which of the following is a key characteristic of the relationship between D and L stereoisomers of a carbohydrate?
Which of the following is a key characteristic of the relationship between D and L stereoisomers of a carbohydrate?
If two glucose molecules combine through a 1-4 glycosidic bond, what disaccharide is formed?
If two glucose molecules combine through a 1-4 glycosidic bond, what disaccharide is formed?
In what form are natural carbohydrates typically found?
In what form are natural carbohydrates typically found?
What structural feature defines whether a polysaccharide is classified as a homopolysaccharide or a heteropolysaccharide?
What structural feature defines whether a polysaccharide is classified as a homopolysaccharide or a heteropolysaccharide?
What is the role of enzymes in carbohydrate chemistry?
What is the role of enzymes in carbohydrate chemistry?
Which of the following best describes the equilibrium that exists for sugars in solution?
Which of the following best describes the equilibrium that exists for sugars in solution?
In the formation of a glycosidic bond, which two functional groups typically react?
In the formation of a glycosidic bond, which two functional groups typically react?
Where are Glycogen branched found?
Where are Glycogen branched found?
What type of linkage primarily connects glucose monomers in glycogen?
What type of linkage primarily connects glucose monomers in glycogen?
Which characteristic of cellulose makes it difficult for most animals to utilize as a primary fuel source?
Which characteristic of cellulose makes it difficult for most animals to utilize as a primary fuel source?
What is the primary structural difference between amylose and amylopectin?
What is the primary structural difference between amylose and amylopectin?
What is the approximate frequency of branching (α1-6 linkages) in amylopectin?
What is the approximate frequency of branching (α1-6 linkages) in amylopectin?
Which of the following describes the role of fungi, protozoa, and bacteria in cellulose metabolism?
Which of the following describes the role of fungi, protozoa, and bacteria in cellulose metabolism?
Which property of cellulose contributes to its structural role in plants?
Which property of cellulose contributes to its structural role in plants?
Which agricultural practice is considered unsustainable due to the potential for alternative uses of plant material?
Which agricultural practice is considered unsustainable due to the potential for alternative uses of plant material?
What critical function does glycogen serve in animals?
What critical function does glycogen serve in animals?
Which statement accurately describes the molecular weight of glycogen?
Which statement accurately describes the molecular weight of glycogen?
What is the role of cellulases in the context of biomass fermentation?
What is the role of cellulases in the context of biomass fermentation?
Which of the following best explains why chitin is considered a tough but flexible material?
Which of the following best explains why chitin is considered a tough but flexible material?
What key enzymatic process is used to convert chitin into chitosan?
What key enzymatic process is used to convert chitin into chitosan?
Vertebrates are unable to digest chitin. What structural feature of chitin is responsible for this?
Vertebrates are unable to digest chitin. What structural feature of chitin is responsible for this?
What is the fundamental structural difference between chitin and chitosan?
What is the fundamental structural difference between chitin and chitosan?
In what capacity is chitin utilized in the medical field, according to the information?
In what capacity is chitin utilized in the medical field, according to the information?
Where is chitin typically found in nature?
Where is chitin typically found in nature?
What role do chitinase enzymes play in the breakdown of chitin?
What role do chitinase enzymes play in the breakdown of chitin?
Individuals with increased expression of chitin-degrading enzymes might be more susceptible to which of the following conditions?
Individuals with increased expression of chitin-degrading enzymes might be more susceptible to which of the following conditions?
Chitin is considered the second most abundant polysaccharide on Earth. What implication does this have for global ecology?
Chitin is considered the second most abundant polysaccharide on Earth. What implication does this have for global ecology?
How do endochitinases differ from exochitinases in their mechanism of action?
How do endochitinases differ from exochitinases in their mechanism of action?
Which component of the ECM is primarily responsible for providing strength and elasticity to tissues?
Which component of the ECM is primarily responsible for providing strength and elasticity to tissues?
How do some tumor cells exploit the ECM to facilitate invasion into tissues?
How do some tumor cells exploit the ECM to facilitate invasion into tissues?
What is the main function of syndecans, a type of integral membrane protein, in relation to the ECM?
What is the main function of syndecans, a type of integral membrane protein, in relation to the ECM?
Which of the following best describes the role of the ECM in relation to individual cells?
Which of the following best describes the role of the ECM in relation to individual cells?
How do cells in connective tissues primarily interact with the ECM?
How do cells in connective tissues primarily interact with the ECM?
How do integrins contribute to cell-ECM interactions?
How do integrins contribute to cell-ECM interactions?
In epithelial cells, what role do specialized collagens and laminins play in relation to the ECM?
In epithelial cells, what role do specialized collagens and laminins play in relation to the ECM?
What is the primary role of the proteins that link the cellular cytoskeleton to the ECM?
What is the primary role of the proteins that link the cellular cytoskeleton to the ECM?
How does the composition of the ECM typically vary between different cell types?
How does the composition of the ECM typically vary between different cell types?
What is the composition of the ECM?
What is the composition of the ECM?
What characteristic distinguishes hyaluronan from other glycosaminoglycans (GAGs)?
What characteristic distinguishes hyaluronan from other glycosaminoglycans (GAGs)?
What is the primary role of glycosaminoglycans (GAGs) in the extracellular matrix (ECM)?
What is the primary role of glycosaminoglycans (GAGs) in the extracellular matrix (ECM)?
Which of the following monomers is a component of the repeating disaccharide units found in glycosaminoglycans?
Which of the following monomers is a component of the repeating disaccharide units found in glycosaminoglycans?
Which tissue or structure relies on chondroitin sulfate for its tensile strength?
Which tissue or structure relies on chondroitin sulfate for its tensile strength?
In which of the following locations is keratan sulfate primarily found?
In which of the following locations is keratan sulfate primarily found?
What role do sperm-secreted hyaluronidase enzymes play in fertilization?
What role do sperm-secreted hyaluronidase enzymes play in fertilization?
Which of the following is a key function of hyaluronan in the human body?
Which of the following is a key function of hyaluronan in the human body?
What is the significance of GAGs being attached to proteins?
What is the significance of GAGs being attached to proteins?
Which structure within the eye benefits from the presence of specific glycosaminoglycans?
Which structure within the eye benefits from the presence of specific glycosaminoglycans?
Which GAG contributes to the structural integrity and function of the walls of the aorta?
Which GAG contributes to the structural integrity and function of the walls of the aorta?
Which characteristic distinguishes heparin sulfate from heparin?
Which characteristic distinguishes heparin sulfate from heparin?
What is the molecular weight range of heparin?
What is the molecular weight range of heparin?
How do glycoconjugates function as information carriers?
How do glycoconjugates function as information carriers?
What is the primary mechanism by which heparin prevents blood clotting?
What is the primary mechanism by which heparin prevents blood clotting?
Which of the following is a function of heparin and heparan sulfate related to pathogens?
Which of the following is a function of heparin and heparan sulfate related to pathogens?
What is a common structural characteristic of proteoglycans?
What is a common structural characteristic of proteoglycans?
What is a key characteristic of glycosaminoglycan (GAG) chains in proteoglycans?
What is a key characteristic of glycosaminoglycan (GAG) chains in proteoglycans?
What is the main role of proteoglycans within the extracellular matrix (ECM)?
What is the main role of proteoglycans within the extracellular matrix (ECM)?
Which statement correctly describes the structure of Syndecans and Glypicans?
Which statement correctly describes the structure of Syndecans and Glypicans?
What broader biological process is regulated by the binding of heparin and heparan sulfate to various cells?
What broader biological process is regulated by the binding of heparin and heparan sulfate to various cells?
What role do viral proteins' heavy glycosylation play in the context of the host's immune system?
What role do viral proteins' heavy glycosylation play in the context of the host's immune system?
In glycoproteins, via which carbon atom is the carbohydrate attached to the protein?
In glycoproteins, via which carbon atom is the carbohydrate attached to the protein?
What role do carbohydrates play in protein-protein recognition?
What role do carbohydrates play in protein-protein recognition?
What is the primary function of lipopolysaccharides (LPS) in Gram-negative bacteria?
What is the primary function of lipopolysaccharides (LPS) in Gram-negative bacteria?
How does the carbohydrate composition of glycolipids in vertebrates relate to blood groups?
How does the carbohydrate composition of glycolipids in vertebrates relate to blood groups?
What is the role of the lipid A portion of bacterial lipopolysaccharides (LPS)?
What is the role of the lipid A portion of bacterial lipopolysaccharides (LPS)?
What is the nature of the linkage between the oligosaccharide chains and the protein in mucins?
What is the nature of the linkage between the oligosaccharide chains and the protein in mucins?
Which components can glycolipids be found in?
Which components can glycolipids be found in?
Which of the following is MOST accurate about the glycosylation of bacterial proteins?
Which of the following is MOST accurate about the glycosylation of bacterial proteins?
How do lipopolysaccharides contribute to infections caused by some bacteria?
How do lipopolysaccharides contribute to infections caused by some bacteria?
Flashcards
What defines an aldose?
What defines an aldose?
Aldoses have a carbonyl group (C=O) at the end of the carbon chain, making them aldehydes.
What defines a ketose?
What defines a ketose?
Ketoses have a carbonyl group (C=O) in the middle of the carbon chain, making them ketones.
What are stereoisomers?
What are stereoisomers?
Molecules with the same molecular formula but different spatial arrangements.
What is optical isomerism?
What is optical isomerism?
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What is a monosaccharide?
What is a monosaccharide?
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What is a disaccharide?
What is a disaccharide?
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What is an oligosaccharide?
What is an oligosaccharide?
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What is a polysaccharide?
What is a polysaccharide?
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What is a chiral center?
What is a chiral center?
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What are glycoproteins and proteoglycans?
What are glycoproteins and proteoglycans?
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What are enantiomers?
What are enantiomers?
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D or L configuration
D or L configuration
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What are anomers?
What are anomers?
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Glycosidic bond
Glycosidic bond
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Homopolysaccharides
Homopolysaccharides
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Heteropolysaccharides
Heteropolysaccharides
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Where are maltose, sucrose, and lactose found?
Where are maltose, sucrose, and lactose found?
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Carb structures
Carb structures
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What is Glycogen?
What is Glycogen?
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What is Cellulose?
What is Cellulose?
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What is starch?
What is starch?
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What is Amylose?
What is Amylose?
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What is Amylopectin?
What is Amylopectin?
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What are cellulases?
What are cellulases?
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Cellulose Structure
Cellulose Structure
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How does Glycogen branch?
How does Glycogen branch?
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What are H bonds?
What are H bonds?
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What is Chitin?
What is Chitin?
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Chitin's Abundance
Chitin's Abundance
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What is Chitosan?
What is Chitosan?
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Chitin Deacetylation
Chitin Deacetylation
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Chitin Fibers
Chitin Fibers
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Chitin Properties
Chitin Properties
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What are Chitinases?
What are Chitinases?
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Chitinase and Allergies
Chitinase and Allergies
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Chitin Location
Chitin Location
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Chitin Applications
Chitin Applications
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ECM function
ECM function
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ECM: Protection
ECM: Protection
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ECM barrier function
ECM barrier function
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ECM Composition
ECM Composition
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ECM Variation
ECM Variation
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Syndecans
Syndecans
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Integrins
Integrins
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ECM Signaling
ECM Signaling
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ECM & Cancer
ECM & Cancer
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Roles of ECM
Roles of ECM
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What are Glycosaminoglycans (GAGs)?
What are Glycosaminoglycans (GAGs)?
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What is the function of GAGs in the ECM?
What is the function of GAGs in the ECM?
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What is the structure of GAGs?
What is the structure of GAGs?
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What is Hyaluronan?
What is Hyaluronan?
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What is Chondroitin sulfate?
What is Chondroitin sulfate?
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What is Keratan sulfate?
What is Keratan sulfate?
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Glycoconjugates
Glycoconjugates
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Heparin
Heparin
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Heparan sulfate
Heparan sulfate
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Iduronic acid 2-sulfate functions
Iduronic acid 2-sulfate functions
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Proteoglycans
Proteoglycans
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Heparin's role in blood clotting
Heparin's role in blood clotting
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Two families of proteoglycans
Two families of proteoglycans
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Glycoconjugates main role
Glycoconjugates main role
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Molecules with highest -ve density
Molecules with highest -ve density
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Proteoglycans' location
Proteoglycans' location
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Glycolipids
Glycolipids
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Glycolipids determine blood groups
Glycolipids determine blood groups
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Bacterial Lipopolysaccharides
Bacterial Lipopolysaccharides
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Lipid A (endotoxin)
Lipid A (endotoxin)
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Glycoproteins
Glycoproteins
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Role of Glycoproteins
Role of Glycoproteins
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Glycosylation in viruses
Glycosylation in viruses
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N-linked/O-linked
N-linked/O-linked
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Bacterial Lipopolysaccharides toxicity
Bacterial Lipopolysaccharides toxicity
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Mucins
Mucins
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Study Notes
Glycolipids
- Lipids with covalently bound oligosaccharide.
- Found in plant and animal cell membranes.
- In vertebrates, carbohydrate composition of glycolipids determines blood groups.
- In Gram-negative bacteria, lipopolysaccharides cover the peptidoglycan layer.
- Immune system targets bacterial lipopolysaccharides.
- Lipid A portion of bacterial lipopolysaccharides is known as endotoxin.
- Bacterial lipopolysaccharides are responsible for toxic shock syndrome associated with some bacterial infections.
Glycoproteins
- Proteins with small oligosaccharides attached.
- Carbohydrate is attached via its anomeric carbon.
- Present in mammalian proteins.
- Carbohydrates play a role in protein-protein recognition.
- Only some bacteria glycosylate a few of their proteins.
- Viral proteins are heavily glycosylated, which helps evade the immune system.
- N-linked/O-linked: serine involves an alcohol group; asparagine involves an amide group.
- Mucins contain large numbers of O-linked oligosaccharide chains.
Glycoconjugates
- Proteins or lipids that have carbohydrates attached.
- Primary function is as information carriers.
- Facilitate communication between cells + surroundings.
- Act as recognition sites for signal molecules.
- Label proteins for transport and degradation.
Heparin and Heparan Sulfate
- Heparin is a linear polymer, with a molecular weight between 3-40 kDa.
- Heparan sulfate is similar to heparin but is attached to proteins.
- They both prevent blood clotting by activating the protease inhibitor antithrombin.
- They bind to various cells and regulate development and formation of blood vessels.
- They can bind to viruses and bacteria, coating them to decrease their virulence.
- Heparan sulfate has the highest negative charge density of biomolecules.
- Iduronic acid 2-sulfate is a component of Heparin and Heparan Sulfate.
Proteoglycans
- Heteropolysaccharides joined to a polypeptide.
- Polysaccharide is a major component.
- Usually structured as a core protein with an attached GAG chain.
- Attached chains are long, linear, and negatively charged.
- They a major component of all ECMs.
- Two families of proteoglycans include Syndecan and Glypican.
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