BDS 2: Oral Mucosa Structure & Function
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BDS 2: Oral Mucosa Structure & Function

Test your knowledge of the oral mucosa, including taste buds, papillae, and tonsils, as well as immunohistochemistry and cell types. Covers material from Dr. S Thavaraj's lecture on BDS 2 Structure and Function of the Oral Mucosa.

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@AchievableYew

Questions and Answers

What is the main difference between pemphigoid and pemphigus?

Pemphigoid causes intra-epithelial separation, while pemphigus causes separation of the epithelium from the lamina propria

What is the time period for the turnover of cells in the gingiva?

41-57 days

What is the function of the progenitor compartment in the oral epithelium?

It contains stem cells, amplifying cells, and maturing cells

What is the name of the layer of cuboidal or columnar cells adjacent to the basal lamina?

<p>Basal layer</p> Signup and view all the answers

What is the clinical significance of desmosomes?

<p>They are important for the maintenance of the integrity of the oral mucosa</p> Signup and view all the answers

What is the primary function of the oral mucosa?

<p>Protection, sensation, and secretion</p> Signup and view all the answers

What is the main difference between the oral mucosa and skin?

<p>Oral mucosa has a higher concentration of non-keratinocytes</p> Signup and view all the answers

What is the layer characterized by the presence of intercellular bridges (‘prickles’)?

<p>Prickle cell layer</p> Signup and view all the answers

What is the function of Langerhan cells in the oral epithelium?

<p>To present antigens to the immune system</p> Signup and view all the answers

Where are taste buds typically found in the oral mucosa?

<p>On the surface of the tongue</p> Signup and view all the answers

What is the term for the combination of epithelium and lamina propria in the oral mucosa?

<p>Mucosa</p> Signup and view all the answers

What is the function of the lamina propria in the oral mucosa?

<p>To provide mechanical support to the epithelium</p> Signup and view all the answers

What is the term for the connection between the oral mucosa and periosteum in the gingiva and hard palate?

<p>Mucoperiosteum</p> Signup and view all the answers

What is the difference between the oral mucosa and skin?

<p>Oral mucosa is non-keratinized, while skin is keratinized</p> Signup and view all the answers

Which of the following cells is NOT a non-keratinocyte in the oral epithelium?

<p>Keratinocytes</p> Signup and view all the answers

What is the function of melanocytes in the oral epithelium?

<p>To synthesize melanin</p> Signup and view all the answers

Where are circumvalate papillae located?

<p>On the surface of the palatine tonsil and tongue</p> Signup and view all the answers

What is the function of the reticulated crypt epithelium in the palatine tonsil?

<p>To trap and remove pathogens</p> Signup and view all the answers

Study Notes

Structure and Function of the Oral Mucosa

  • The oral mucosa maintains structural integrity through a process of continual renewal, involving two functional populations: progenitor population and maturing population.
  • The progenitor compartment contains stem cells, amplifying cells, and has a turnover time of:
    • 41-57 days in the gingiva
    • 25 days in the buccal mucosa

Basal Layer (Stratum Basale)

  • The basal layer is the layer of cuboidal or columnar cells immediately adjacent to the basal lamina.
  • Mitosis occurs in the basal layer.
  • The basal lamina is a critical component of the epithelium, separating it from the lamina propria.
  • Clinical significance of the basal lamina: pemphigoid, a blistering disease characterized by autoantibodies to the bullous pemphigoid antigen.

Prickle Cell Layer (Stratum Spinosum)

  • The prickle cell layer is characterized by intercellular bridges (‘prickles’) and desmosomes.
  • Clinical significance of desmosomes: pemphigus, characterized by autoantibodies to desmoglein, resulting in intra-epithelial separation.
  • The separation differs from pemphigoid in that it occurs within the epithelium rather than between the epithelium and lamina propria.

Function of the Oral Mucosa

  • Protection
  • Sensation
  • Secretion
  • The oral mucosa consists of epithelium and lamina propria (corium).

Epithelium and Lamina Propria

  • The boundary between the mucosa and submucosa in the oral and intestinal epithelia is the lamina propria.
  • The connective tissue papillae are located in the lamina propria.

Mucoperiosteum

  • In the gingiva and parts of the hard palate, the oral mucosa lies in continuity with periosteum without any intervening submucosa.
  • Functional and clinical significance of the mucoperiosteum: uncertainty.

Non-Keratinocytes within the Oral Epithelium

  • Langerhans cells:
    • Antigen-presenting cells
    • Derived from bone marrow
    • Move in and out of the epithelium
    • Dendritic, CD1a and S100 +ve
    • Contain Birbeck granules
  • Melanocytes:
    • Neural crest derivatives
    • Dendritic, no desmosomes
    • Synthesize melanin in melanosomes
    • Ubiquitous, S100, HMB45, and MelanA +ve

Additional Questions

  • What other non-keratinocytes are present within the oral epithelium?
  • What are the differences between skin and oral mucosa?
  • What are the key features of crevicular (sulcular) and junctional epithelium?
  • What cells make up the lamina propria?
  • What are keratins, what is their function, and how may they be classified?

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