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Questions and Answers
What are the functional units of the nervous system?
What are the functional units of the nervous system?
Neurons
What are the three types of neurons?
What are the three types of neurons?
Sensory or afferent neurons, motor or efferent neurons, and interneurons
Which of the following is NOT a function of the nervous system?
Which of the following is NOT a function of the nervous system?
What are the non-neuronal cells that support and protect the brain's neurons called?
What are the non-neuronal cells that support and protect the brain's neurons called?
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Which type of neuroglia is responsible for the formation of myelin in the central nervous system?
Which type of neuroglia is responsible for the formation of myelin in the central nervous system?
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Which of the following is a neurotransmitter that is generally excitatory?
Which of the following is a neurotransmitter that is generally excitatory?
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What is the name of the degenerative disorder of the central nervous system that affects motor skills, speech, and other functions?
What is the name of the degenerative disorder of the central nervous system that affects motor skills, speech, and other functions?
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What is the name of the mental disorder characterized by a disintegration of the process of thinking and of emotional responsiveness?
What is the name of the mental disorder characterized by a disintegration of the process of thinking and of emotional responsiveness?
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What is the name of the neurotransmitter that is generally inhibitory?
What is the name of the neurotransmitter that is generally inhibitory?
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Which of the following is a neurotransmitter that is secreted by the CNS and at invertebrate neuromuscular junctions?
Which of the following is a neurotransmitter that is secreted by the CNS and at invertebrate neuromuscular junctions?
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Which of the following is a neurotransmitter that is excitatory to skeletal muscle, but inhibitory to cardiac muscle?
Which of the following is a neurotransmitter that is excitatory to skeletal muscle, but inhibitory to cardiac muscle?
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What are the two main divisions of the vertebrate nervous system?
What are the two main divisions of the vertebrate nervous system?
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What is the name of a cluster of nerve cell bodies within the peripheral nervous system?
What is the name of a cluster of nerve cell bodies within the peripheral nervous system?
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Which part of the brain is responsible for regulating autonomic activity, such as thermoregulation, hunger, and thirst?
Which part of the brain is responsible for regulating autonomic activity, such as thermoregulation, hunger, and thirst?
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Which part of the brain is involved in the coordination of movement, muscle tone, posture, and balance?
Which part of the brain is involved in the coordination of movement, muscle tone, posture, and balance?
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Which part of the brain is responsible for relaying sensory information to the cerebrum, and also plays a role in regulating emotion and arousal?
Which part of the brain is responsible for relaying sensory information to the cerebrum, and also plays a role in regulating emotion and arousal?
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What are the two main types of nerve signals?
What are the two main types of nerve signals?
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Action potentials are all-or-nothing events, meaning that they either occur fully or not at all.
Action potentials are all-or-nothing events, meaning that they either occur fully or not at all.
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What is the term for the process by which action potentials are conducted more quickly in myelinated neurons?
What is the term for the process by which action potentials are conducted more quickly in myelinated neurons?
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What is the name of the small gap between two neurons at a synapse?
What is the name of the small gap between two neurons at a synapse?
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Which of the following is NOT a type of neurotransmitter?
Which of the following is NOT a type of neurotransmitter?
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What is the name of the fluid that fills the ventricles of the brain and the central canal of the spinal cord?
What is the name of the fluid that fills the ventricles of the brain and the central canal of the spinal cord?
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White matter in the brain and spinal cord is composed of myelinated axons, while gray matter is composed of unmyelinated axons, nuclei, and dendrites.
White matter in the brain and spinal cord is composed of myelinated axons, while gray matter is composed of unmyelinated axons, nuclei, and dendrites.
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What is the name of the autonomic response that involves a simple nerve circuit?
What is the name of the autonomic response that involves a simple nerve circuit?
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Which part of the brain is responsible for processing visual information?
Which part of the brain is responsible for processing visual information?
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Which part of the brain is responsible for integrating auditory information with other sensory inputs?
Which part of the brain is responsible for integrating auditory information with other sensory inputs?
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Which of the following is NOT a part of the brainstem?
Which of the following is NOT a part of the brainstem?
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What part of the brain functions as a biological clock?
What part of the brain functions as a biological clock?
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The right hemisphere of the brain specializes in language, math, logic operations, and the processing of serial sequences of information.
The right hemisphere of the brain specializes in language, math, logic operations, and the processing of serial sequences of information.
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Which part of the brain is typically responsible for speech production?
Which part of the brain is typically responsible for speech production?
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Which part of the brain is typically responsible for the comprehension of speech?
Which part of the brain is typically responsible for the comprehension of speech?
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Which of the following is NOT a component of the limbic system?
Which of the following is NOT a component of the limbic system?
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What are the two types of memory that are involved in memory and learning?
What are the two types of memory that are involved in memory and learning?
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The transfer of information from short-term to long-term memory is NOT influenced by emotional states.
The transfer of information from short-term to long-term memory is NOT influenced by emotional states.
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How many pairs of cranial nerves are there in humans?
How many pairs of cranial nerves are there in humans?
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Which of the following is NOT a type of sensory receptor?
Which of the following is NOT a type of sensory receptor?
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What is the name of the process by which sensory receptors convert stimulus energy into signals that can be interpreted by the nervous system?
What is the name of the process by which sensory receptors convert stimulus energy into signals that can be interpreted by the nervous system?
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What type of sensory receptor detects mechanical energy?
What type of sensory receptor detects mechanical energy?
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What type of sensory receptor detects chemical stimuli?
What type of sensory receptor detects chemical stimuli?
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What type of sensory receptor detects electromagnetic energy, such as visible light?
What type of sensory receptor detects electromagnetic energy, such as visible light?
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Eye cups, the simplest photoreceptors, detect light intensity and direction, but they do not form images.
Eye cups, the simplest photoreceptors, detect light intensity and direction, but they do not form images.
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In insects and crustaceans, what type of eye forms images by using ommatidia?
In insects and crustaceans, what type of eye forms images by using ommatidia?
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Which of the following is an example of an animal with a single-lens eye?
Which of the following is an example of an animal with a single-lens eye?
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What is the name of the process by which the vertebrate eye focuses light on the retina?
What is the name of the process by which the vertebrate eye focuses light on the retina?
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In mammals, which type of photoreceptor is responsible for vision in dim light?
In mammals, which type of photoreceptor is responsible for vision in dim light?
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In mammals, which type of photoreceptor is responsible for color vision?
In mammals, which type of photoreceptor is responsible for color vision?
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The absorption of light by rhodopsin, the visual pigment in rod cells, initiates a signal transduction pathway.
The absorption of light by rhodopsin, the visual pigment in rod cells, initiates a signal transduction pathway.
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In the vertebrate eye, how do rods and cones synapse with bipolar cells?
In the vertebrate eye, how do rods and cones synapse with bipolar cells?
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The optic nerves of the two eyes meet at the optic chiasm, where the nasal half of each tract crosses to the opposite side.
The optic nerves of the two eyes meet at the optic chiasm, where the nasal half of each tract crosses to the opposite side.
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Where in the thalamus do most of the ganglion cell axons from the optic tract synapse?
Where in the thalamus do most of the ganglion cell axons from the optic tract synapse?
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What is the name of the fluid that fills the cochlear duct?
What is the name of the fluid that fills the cochlear duct?
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Which of the following is NOT a part of the inner ear?
Which of the following is NOT a part of the inner ear?
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What is the name of the structure in the cochlea that contains hair cells and is responsible for sound transduction?
What is the name of the structure in the cochlea that contains hair cells and is responsible for sound transduction?
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What is the name of the membrane that vibrates in response to vibrations in the cochlear fluid and causes hair cells to brush against the tectorial membrane?
What is the name of the membrane that vibrates in response to vibrations in the cochlear fluid and causes hair cells to brush against the tectorial membrane?
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The pitch of a sound is determined by the frequency of the sound wave, while the volume of a sound is determined by the amplitude of the sound wave.
The pitch of a sound is determined by the frequency of the sound wave, while the volume of a sound is determined by the amplitude of the sound wave.
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What type of sensory receptor is responsible for detecting the position and movement of the head and body in an invertebrate?
What type of sensory receptor is responsible for detecting the position and movement of the head and body in an invertebrate?
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In insects, what is the name of the membrane that is stretched over a hollow chamber and vibrates in response to sound waves?
In insects, what is the name of the membrane that is stretched over a hollow chamber and vibrates in response to sound waves?
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In mammals, taste receptors are located in taste buds, most of which are found on the surface of the tongue.
In mammals, taste receptors are located in taste buds, most of which are found on the surface of the tongue.
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Each taste receptor cell is highly specific, responding to only one type of chemical.
Each taste receptor cell is highly specific, responding to only one type of chemical.
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Which of the following is NOT a taste that humans can typically detect?
Which of the following is NOT a taste that humans can typically detect?
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In mammals, olfactory receptors are located in the nasal cavity and are responsible for detecting smells.
In mammals, olfactory receptors are located in the nasal cavity and are responsible for detecting smells.
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Olfactory receptor cells are not sensory neurons.
Olfactory receptor cells are not sensory neurons.
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What is the name of the part of the brain that receives signals from olfactory receptor cells and processes information related to smell?
What is the name of the part of the brain that receives signals from olfactory receptor cells and processes information related to smell?
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Study Notes
Nervous Coordination
- The nervous system detects external and internal stimuli.
- It controls and coordinates responses to stimuli.
- The nervous system includes the brain, spinal cord, and sense organs.
Neurons: Functional Units of Nervous System
- Neurons are the functional units of the nervous system.
- Types of neurons include: sensory (afferent), motor (efferent), and interneurons.
- Neurons have dendrites to receive signals, a cell body, an axon to transmit signals, a myelin sheath, and axon terminal branches.
- Signals travel from dendrites to the axon terminal branches.
- The synapse is the junction between neurons.
- The presynaptic cell releases neurotransmitters.
- The postsynaptic cell receives neurotransmitters.
Neuroglia
- Neuroglia, also called glial cells, are non-neuronal cells.
- They maintain homeostasis, form myelin, and support/protect neurons.
- Examples include astrocytes, oligodendrocytes, and microglia.
Astrocytes
- Astrocytes provide biochemical support to endothelial cells forming the blood-brain barrier.
- They supply nutrients to nervous tissue.
- They maintain extracellular ion balance.
- They play a significant role in repair and scarring of brain and spinal cord after injury.
Oligodendrocytes
- Oligodendrocytes insulate axons in the central nervous system (brain and spinal cord) of higher vertebrates.
- They provide nutrients to nervous tissue.
Microglia
- Microglia are resident macrophages of the brain and spinal cord.
- They are the primary form of active immune defense in the central nervous system.
Patterns of Organization of Nervous Systems
- Nerve nets are found in simple animals like hydra and sea stars.
- Cephalization, the concentration of nervous tissue, leads to more complex nervous systems.
Nature of Nerve Signals
- Every cell has a voltage or membrane potential across its plasma membrane.
- A membrane potential is a localized electrical gradient across the membrane.
- Anions are more concentrated within a cell.
- Cations are more concentrated in the extracellular fluid.
- An unstimulated cell usually has a resting potential of -70 mV.
How a Cell Maintains Membrane Potential
- The principal intracellular cation is K+.
- Na+ is the principal extracellular cation.
- Proteins, amino acids, sulfate, and phosphate are principal intracellular anions.
- Cl– is the principal extracellular anion.
Ungated Ion Channels
- Ungated ion channels allow ions to diffuse across the plasma membrane; they are always open.
Excitation
- Changes in membrane potential trigger nerve impulses.
- Excitation of cells involves opening or closing of gated ion channels.
- Subsequent ion diffusion changes membrane potential.
Types of Gated Ions
- Chemically-gated ion channels open/close in response to a chemical stimulus.
- Voltage-gated ion channels open/close in response to a change in membrane potential.
Graded Potentials
- Graded potentials are changes in membrane potential (hyperpolarization & depolarization)
Action Potential
- The summation of graded potentials may reach a threshold (-55mV).
- This triggers an action potential.
- An action potential is an all-or-nothing response.
- Action potentials propagate along axons only.
Voltage-gated Na+ Channels
- Voltage-gated Na+ channels have activation gates (open rapidly in response to depolarization) and inactivation gates (close slowly in response to depolarization).
- These channels are crucial in the action potential.
Saltatory Conduction
- In myelinated neurons, the action potential jumps between nodes of Ranvier.
- This speeds up impulse transmission.
Synapses
- Electrical synapses: the action potential travels directly via gap junctions between presynaptic and postsynaptic cells.
- Chemical synapses: the action potential triggers release of neurotransmitters from the presynaptic terminal, which diffuse across the synaptic cleft and act on receptors of the postsynaptic cell; postsynaptic cell channels for ions such as Na+, K+, and Cl– then open/close resulting in depolarization or hyperpolarization.
Neurotransmitters
- Examples: acetylcholine, biogenic amines (epinephrine, norepinephrine), dopamine, serotonin, amino acids (GABA, glycine, glutamate, aspartate), neuropeptides (substance P, endorphins), and gases (nitric oxide, carbon monoxide).
- Different neurotransmitters have various effects: excitatory or inhibitory on target cells.
Parkinson’s disease
- A degenerative disorder of the central nervous system impairing motor skills, speech, and other functions.
- Symptoms include muscle rigidity, tremor, postural abnormalities, slowed movement (bradykinesia), and loss of movement (akinesia).
Schizophrenia
- A mental disorder characterized by the disintegration of thought processes and emotions.
- Symptoms include auditory hallucinations, paranoid or bizarre delusions, disorganized speech and thinking, and significant social or occupational dysfunction.
Vertebrate Nervous Systems
- The vertebrate nervous system is divided into the central nervous system (CNS) and peripheral nervous system (PNS).
- The CNS includes the brain and spinal cord.
- The PNS includes cranial nerves, and ganglia outside the CNS as well as spinal nerves.
- The PNS is further separated into sensory (afferent) and motor (efferent) divisions.
- The motor division is further separated into somatic and autonomic divisions.
- The autonomic division is further separated into sympathetic and parasympathetic divisions.
- The motor division is further separated into somatic and autonomic divisions.
Ganglia and Nuclei
- A ganglion is a cluster of nerve cell bodies found in the peripheral nervous system.
- A nucleus is a cluster of nerve cells in the central nervous system.
Cranial Nerves
- There are 12 pairs of cranial nerves in humans.
- Some cranial nerves have both sensory and motor functions.
- Some originate from the cerebrum.
- Others from the brainstem.
Sensory Systems
- Sensations begin as different forms of energy detected by sensory receptors.
- Receptors convert stimulus energy to action potentials that travel to appropriate areas of the brain.
- Sensations are action potentials reaching the brain carried by sensory neurons.
- Perception is the awareness and interpretation of the sensation.
- Sensory reception involves transduction, amplification, transmission, and integration.
Sensory Transduction
- Conversion of stimulus energy (e.g., light, pressure) into a change in membrane potential, a receptor potential.
- Involves special receptors unique to the various forms of energy (e.g., photoreceptors for light).
Sensory Receptors
- Special receptors that detect specific forms of energy like heat, light, pain, pressure, and chemicals. (examples of mechanoreceptors, pain receptors, thermoreceptors, chemoreceptors, photoreceptors)
- Exteroreceptors detect stimuli originating outside the body.
- Interoreceptors detect stimuli originating inside the body.
Types of Receptors
- Mechanoreceptors: respond to mechanical energy (e.g., pressure, touch, stretch).
- Pain receptors: respond to damaging stimuli.
- Thermoreceptors: respond to heat or cold.
- Chemoreceptors: respond to chemical stimuli (e.g., taste, smell, changes in blood composition).
- Electromagnetic receptors: respond to electromagnetic energy (e.g., light).
Photoreception
- Photoreceptors (e.g., rod cells and cone cells) detect light.
- Simple photoreceptors (e.g., eye cups) detect light intensity and direction.
- Compound eyes (e.g., insects) consist of ommatidia, each with a light-focusing lens.
- Single-lens eyes (e.g., invertebrates like octopus) work like a camera.
- Vertebrate eyes have a cornea, lens, retina (photoreceptors), and supporting structures.
- Accommodation in mammals involves changing the shape of the lens to focus light.
Human Retina
- Contains about 125 million rod cells (low light vision) and 6 million cone cells (color vision).
Visual Processing in Retina
- Visual processing begins with rods and cones synapsing with bipolar cells, then with ganglion cells.
- Horizontal and amacrine cells are involved in lateral inhibition (enhancing contrast).
Hearing and Equilibrium
- Sound waves travel to the cochlea and stimulate hair cells generating an action potential (carried by the auditory nerve).
- Pitch depends on where on the basilar membrane the hair cells that depolarize are located.
- Volume depends on the amplitude of the sound waves.
- The inner ear also contains equilibrium organs (semicircular canals, utricle, saccule) that detect rotational and linear acceleration, respectively.
Chemoreception
- Taste receptors in insects are on their feet.
- Mammal taste receptors are in taste buds on the tongue.
- Each receptor responds to a range of chemicals.
- Olfactory receptors in mammals line the nasal cavity.
Brain Regions: Structure and Function
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Forebrain - includes telencephalon and diencephalon
-
Midbrain - includes mesencephalon
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Hindbrain - includes metencephalon and myelencephalon
-
Structures within the brain and their functions: -Cerebrum (cerebral cortex, basal nuclei) – higher-order functions -Diencephalon (thalamus, hypothalamus, epithalamus) – coordinating functions -Midbrain – contains nuclei for sensory integration -Cerebellum – coordination of motor activities; integrates sensory information -Medulla oblongata, pons – control basic life functions (e.g., breathing, heart rate)
Embryonic Development of the Brain
- Development of different brain regions from three embryonic vesicles (forebrain, midbrain, hindbrain).
- Transformations of structures during prenatal development into adult structures
Lateralization of Brain Function
- Specialization of the left and right hemispheres of the brain for different functions -Left - language, math, logic -Right - spatial reasoning, pattern recognition, emotions, parallel processing
Language and Speech
- Broca's area: responsible for speech production.
- Wernicke's area: responsible for speech comprehension.
The Limbic System
- Network of brain structures: amygdala, hippocampus, olfactory cortex, inner portions of cortex lobes, parts of the thalamus and hypothalamus
- Mediate basic emotions (e.g., fear, anger), emotional memory, emotional content of facial expressions.
Memory & Learning
- Short-term memory stored in frontal lobes.
- Establishment of long-term memory involves the hippocampus.
- Transfer from short-term to long-term memory is enhanced by repetition and emotion.
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